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Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants
[Image: see text] The development of novel non-nucleoside inhibitors (NNRTIs) with activity against variants of HIV reverse transcriptase (RT) is crucial for overcoming treatment failure. The NNRTIs bind in an allosteric pocket in RT ∼10 Å away from the active site. Earlier analogues of the catechol...
Guardat en:
| Publicat a: | J Med Chem |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2015
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4378236/ https://ncbi.nlm.nih.gov/pubmed/25700160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501908a |
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