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Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation
The Polycomb group protein Bmi-1 is an essential regulator of cellular senescence and is believed to function largely through the direct repression of the Ink4a/Arf locus. However, concurrent deletion of Ink4a/Arf does not fully rescue the defects detected in Bmi-1(−/−) mice, indicating that additio...
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| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4377314/ https://ncbi.nlm.nih.gov/pubmed/25263442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.322 |
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