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Sin3B expression is required for cellular senescence and is upregulated upon oncogenic stress
Serial passage of primary mammalian cells or strong mitogenic signals induces a permanent exit from the cell cycle called senescence. A characteristic of senescent cells is the heterochromatinization of loci encoding pro-proliferative genes leading to their transcriptional silencing. Senescence is t...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2782780/ https://ncbi.nlm.nih.gov/pubmed/19654306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0537 |
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