Sin3B expression is required for cellular senescence and is upregulated upon oncogenic stress

Serial passage of primary mammalian cells or strong mitogenic signals induces a permanent exit from the cell cycle called senescence. A characteristic of senescent cells is the heterochromatinization of loci encoding pro-proliferative genes leading to their transcriptional silencing. Senescence is t...

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Bibliografiske detaljer
Main Authors: Grandinetti, Kathryn B., Jelinic, Petar, DiMauro, Teresa, Pellegrino, Jessica, Rodriguez, Ruben Fernandez, Finnerty, Patricia M., Ruoff, Rachel, Bardeesy, Nabeel, Logan, Susan K., David, Gregory
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782780/
https://ncbi.nlm.nih.gov/pubmed/19654306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0537
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