Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in neurodegenerative disease. Here we find that a key consequence of ROS and neuronal mitochondrial dysfunction is the accumulation of lipid droplets (LD) in glia. In Drosophila, ROS triggers c-Jun-N-terminal Kinase (J...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell
Autores principales: Liu, Lucy, Zhang, Ke, Sandoval, Hector, Yamamoto, Shinya, Jaiswal, Manish, Sanz, Elisenda, Li, Zhihong, Hui, Jessica, Graham, Brett H., Quintana, Albert, Bellen, Hugo J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377295/
https://ncbi.nlm.nih.gov/pubmed/25594180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.12.019
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares