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Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in neurodegenerative disease. Here we find that a key consequence of ROS and neuronal mitochondrial dysfunction is the accumulation of lipid droplets (LD) in glia. In Drosophila, ROS triggers c-Jun-N-terminal Kinase (J...
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| Veröffentlicht in: | Cell |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4377295/ https://ncbi.nlm.nih.gov/pubmed/25594180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.12.019 |
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