Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in neurodegenerative disease. Here we find that a key consequence of ROS and neuronal mitochondrial dysfunction is the accumulation of lipid droplets (LD) in glia. In Drosophila, ROS triggers c-Jun-N-terminal Kinase (J...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell
Main Authors: Liu, Lucy, Zhang, Ke, Sandoval, Hector, Yamamoto, Shinya, Jaiswal, Manish, Sanz, Elisenda, Li, Zhihong, Hui, Jessica, Graham, Brett H., Quintana, Albert, Bellen, Hugo J.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377295/
https://ncbi.nlm.nih.gov/pubmed/25594180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.12.019
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki