Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation

BACKGROUND: Chronic neuroinflammation and calcium (Ca(+2)) dysregulation are both components of Alzheimer’s disease. Prolonged neuroinflammation produces elevation of pro-inflammatory cytokines and reactive oxygen species which can alter neuronal Ca(+2) homeostasis via L-type voltage-dependent Ca(+2...

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Udgivet i:J Neuroinflammation
Main Authors: Hopp, Sarah C, D’Angelo, Heather M, Royer, Sarah E, Kaercher, Roxanne M, Crockett, Alexis M, Adzovic, Linda, Wenk, Gary L
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
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Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377218/
https://ncbi.nlm.nih.gov/pubmed/25888781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0262-3
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