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Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population
BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene. Patients with low or undetectable TMPT activity could develop severe myelosuppress...
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| Publicado no: | Libyan J Med |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Co-Action Publishing
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376936/ https://ncbi.nlm.nih.gov/pubmed/25819542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/ljm.v10.27053 |
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