Polymorphisms of the thiopurine S-methyltransferase gene among the Libyan population

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses the S-methylation of 6-mercaptopurine and azathioprine. Low activity phenotypes are correlated with polymorphism in the TPMT gene. Patients with low or undetectable TMPT activity could develop severe myelosuppress...

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Pubblicato in:Libyan J Med
Autori principali: Zeglam, Hamza Ben, Benhamer, Abdrazak, Aboud, Adel, Rtemi, Haitem, Mattardi, Meftah, Saleh, Saleh Suleiman, Bashein, Abdullah, Enattah, Nabil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Co-Action Publishing 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376936/
https://ncbi.nlm.nih.gov/pubmed/25819542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3402/ljm.v10.27053
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