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STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel
The ER-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with the plasma membrane Ca(2+) channel ORAI1. The mechanism of channel gating remains undefined. Here we establish that STIM1 gates the purified recombinant ORAI1 channel in vitro, and use Tb(3+) lum...
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| Vydáno v: | Nat Commun |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376667/ https://ncbi.nlm.nih.gov/pubmed/25296861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6164 |
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