Dimorphic effects of TGFβ signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome

OBJECTIVE: Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of non-canonical (Erk-mediated) TGFβ signaling by the angiotensin type I receptor (AT1r). This correlation was largely based on comparable TAA modifi...

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Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Cook, Jason R., Clayton, Nicholas P., Carta, Luca, Galatioto, Josephine, Chiu, Emily, Smaldone, Silvia, Nelson, Carol A., Cheng, Seng H., Wentworth, Bruce M., Ramirez, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376614/
https://ncbi.nlm.nih.gov/pubmed/25614286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.305150
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