NRBF2 Regulates Autophagy and Prevents Liver Injury by Modulating Atg14L-Linked Phosphatidylinositol-3 Kinase III Activity

The Beclin 1-Vps34 complex, the core component of the class III phosphatidylinositol-3 kinase (PI3K-III), binds Atg14L or UVRAG to control different steps of autophagy. However, the mechanism underlying the control of PI3K-III activity remains elusive. Here we report the identification of NRBF2 as a...

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Udgivet i:Nat Commun
Main Authors: Lu, Jiahong, He, Liqiang, Behrends, Christian, Araki, Masatake, Araki, Kimi, Wang, Qing Jun, Catanzaro, Joseph M., Friedman, Scott L., Zong, Wei-Xing, Fiel, M. Isabel, Li, Min, Yue, Zhenyu
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376476/
https://ncbi.nlm.nih.gov/pubmed/24849286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4920
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