Nrbf2 Protein Suppresses Autophagy by Modulating Atg14L Protein-containing Beclin 1-Vps34 Complex Architecture and Reducing Intracellular Phosphatidylinositol-3 Phosphate Levels

Autophagy is a tightly regulated lysosomal degradation pathway for maintaining cellular homeostasis and responding to stresses. Beclin 1 and its interacting proteins, including the class III phosphatidylinositol-3 kinase Vps34, play crucial roles in autophagy regulation in mammals. We identified nuc...

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Detalhes bibliográficos
Main Authors: Zhong, Yu, Morris, Deanna H., Jin, Lin, Patel, Mittul S., Karunakaran, Senthil K., Fu, You-Jun, Matuszak, Emily A., Weiss, Heidi L., Chait, Brian T., Wang, Qing Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176228/
https://ncbi.nlm.nih.gov/pubmed/25086043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.561134
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