S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms

BACKGROUND AND PURPOSE: Sphingosine-1-phosphate (S1P) has been shown to be involved in the asthmatic disease as well in preclinical mouse experimental models of this disease. The aim of this study was to understand the mechanism(s) underlying S1P effects on the lung. EXPERIMENTAL APPROACH: BALB/c, m...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Roviezzo, F, Sorrentino, R, Bertolino, A, De Gruttola, L, Terlizzi, M, Pinto, A, Napolitano, M, Castello, G, D'Agostino, B, Ianaro, A, Cirino, G
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376464/
https://ncbi.nlm.nih.gov/pubmed/25439580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13033
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