High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis

BACKGROUND AND PURPOSE: Selective agonists of the sigma-1 receptor (σ1 protein) are generally reported to protect against neuronal damage and modulate oligodendrocyte differentiation. Human and rodent lymphocytes possess saturable, high-affinity binding sites for compounds binding to the σ1 protein...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Oxombre, B, Lee-Chang, C, Duhamel, A, Toussaint, M, Giroux, M, Donnier-Maréchal, M, Carato, P, Lefranc, D, Zéphir, H, Prin, L, Melnyk, P, Vermersch, P
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376455/
https://ncbi.nlm.nih.gov/pubmed/25521311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13037
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