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Mitochondrial (dys)function – a factor underlying the variability of efavirenz-induced hepatotoxicity?
BACKGROUND AND PURPOSE: The non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence has pinpointed a specific mitochondrial action of efavirenz accompanied by the...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376451/ https://ncbi.nlm.nih.gov/pubmed/25411110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13018 |
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