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Enhanced oxidative stress and increased mitochondrial mass during Efavirenz-induced apoptosis in human hepatic cells

BACKGROUND AND PURPOSE: Efavirenz (EFV) is widely used in the treatment of HIV-1 infection. Though highly efficient, there is growing concern about EFV-related side effects, the molecular basis of which remains elusive. EXPERIMENTAL APPROACH: In vitro studies were performed to address the effect of...

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Detalhes bibliográficos
Main Authors: Apostolova, N, Gomez-Sucerquia, LJ, Moran, A, Alvarez, A, Blas-Garcia, A, Esplugues, JV
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958650/
https://ncbi.nlm.nih.gov/pubmed/20649602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00866.x
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