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Mitochondrial disease in mouse results in increased oxidative stress

It has been hypothesized that a major factor in the progression of mitochondrial disease resulting from defects in oxidative phosphorylation (OXPHOS) is the stimulation of the mitochondrial production of reactive oxygen species (ROS) and the resulting damage to the mtDNA. To test this hypothesis, we...

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Détails bibliographiques
Auteurs principaux: Esposito, Luke A., Melov, Simon, Panov, Alexander, Cottrell, Barbara A., Wallace, Douglas C.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC21775/
https://ncbi.nlm.nih.gov/pubmed/10220377
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