MITOCHONDRIAL OXIDATIVE STRESS IN MICE LACKING THE GLUTATHIONE PEROXIDASE-1 GENE

Oxidative stress resulting from mitochondrially derived reactive oxygen species (ROS) has been hypothesized to damage mitochondrial oxidative phosphorylation (OXPHOS) and to be a factor in aging and degenerative disease. If this hypothesis is correct, then genetically inactivating potential mitochon...

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Bibliographic Details
Main Authors: Esposito, Luke A., Kokoszka, Jason E., Waymire, Katrina G., Cottrell, Barbara, MacGregor, Grant R., Wallace, Douglas C.
Format: Artigo
Language:Inglês
Published: 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049813/
https://ncbi.nlm.nih.gov/pubmed/10754271
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