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Maximal acceleration of Ca(2+) release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes

Time-dependent refractoriness of calcium (Ca(2+)) release in cardiac myocytes is an important factor in determining whether pro-arrhythmic release patterns develop. At the subcellular level of the Ca(2+) spark, recent studies have suggested that recovery of spark amplitude is controlled by local sar...

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Publicat a:J Physiol
Autors principals: Poláková, Eva, Illaste, Ardo, Niggli, Ernst, Sobie, Eric A
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376426/
https://ncbi.nlm.nih.gov/pubmed/25772298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.278051
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