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Lower Expression of Glutamic Acid Decarboxylase 67 in the Prefrontal Cortex in Schizophrenia: Contribution of Altered Regulation by Zif268

OBJECTIVE: Cognitive deficits of schizophrenia may be due at least in part to lower expression of the 67-kDa isoform of glutamic acid decarboxylase (GAD67), a key enzyme for GABA synthesis, in the dorsolateral prefrontal cortex of individuals with schizophrenia. However, little is known about the mo...

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Detalhes bibliográficos
Publicado no:Am J Psychiatry
Main Authors: Kimoto, Sohei, Bazmi, H. Holly, Lewis, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376371/
https://ncbi.nlm.nih.gov/pubmed/24874453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2014.14010004
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