Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis

Aims: Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H(2)O(2)) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the impact of targeted disruption of Txnrd2 on tum...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Hellfritsch, Juliane, Kirsch, Julian, Schneider, Manuela, Fluege, Tamara, Wortmann, Markus, Frijhoff, Jeroen, Dagnell, Markus, Fey, Theres, Esposito, Irene, Kölle, Pirkko, Pogoda, Kristin, Angeli, José Pedro Friedmann, Ingold, Irina, Kuhlencordt, Peter, Östman, Arne, Pohl, Ulrich, Conrad, Marcus, Beck, Heike
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376289/
https://ncbi.nlm.nih.gov/pubmed/25647640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2014.5889
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