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Bypass of genetic constraints during mutator evolution to antibiotic resistance
Genetic constraints can block many mutational pathways to optimal genotypes in real fitness landscapes, yet the extent to which this can limit evolution remains to be determined. Interestingly, mutator bacteria elevate only specific types of mutations, and therefore could be very sensitive to geneti...
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| Publicat a: | Proc Biol Sci |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Royal Society
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375862/ https://ncbi.nlm.nih.gov/pubmed/25716795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2014.2698 |
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