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Bypass of genetic constraints during mutator evolution to antibiotic resistance

Genetic constraints can block many mutational pathways to optimal genotypes in real fitness landscapes, yet the extent to which this can limit evolution remains to be determined. Interestingly, mutator bacteria elevate only specific types of mutations, and therefore could be very sensitive to geneti...

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Detalhes bibliográficos
Publicado no:Proc Biol Sci
Main Authors: Couce, Alejandro, Rodríguez-Rojas, Alexandro, Blázquez, Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375862/
https://ncbi.nlm.nih.gov/pubmed/25716795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2014.2698
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