Sirtuin 1 Is a Negative Regulator of Parathyroid Hormone Stimulation of Matrix Metalloproteinase 13 Expression in Osteoblastic Cells: ROLE OF SIRTUIN 1 IN THE ACTION OF PTH ON OSTEOBLASTS

Parathyroid hormone (PTH) is the only current anabolic treatment for osteoporosis in the United States. PTH stimulates expression of matrix metalloproteinase 13 (MMP13) in bone. Sirtuin 1 (SIRT1), an NAD-dependent deacetylase, participates in a variety of human diseases. Here we identify a role for...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Fei, Yurong, Shimizu, Emi, McBurney, Michael W., Partridge, Nicola C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375490/
https://ncbi.nlm.nih.gov/pubmed/25631045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602763
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