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Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM
Deregulation of epidermal growth factor receptor (EGFR) signaling has been correlated with the development of a variety of human carcinomas. EGF-induced receptor dimerization and consequent trans- auto-phosphorylation are among the earliest events in signal transduction. Binding of EGF is thought to...
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Izdano u: | Biophys J |
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Glavni autori: | , , , , , , , , , , , , , , , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
The Biophysical Society
2015
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Teme: | |
Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4375452/ https://ncbi.nlm.nih.gov/pubmed/25762314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.01.005 |
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