Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM

Deregulation of epidermal growth factor receptor (EGFR) signaling has been correlated with the development of a variety of human carcinomas. EGF-induced receptor dimerization and consequent trans- auto-phosphorylation are among the earliest events in signal transduction. Binding of EGF is thought to...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Coban, Oana, Zanetti-Dominguez, Laura C., Matthews, Daniel R., Rolfe, Daniel J., Weitsman, Gregory, Barber, Paul R., Barbeau, Jody, Devauges, Viviane, Kampmeier, Florian, Winn, Martyn, Vojnovic, Borivoj, Parker, Peter J., Lidke, Keith A., Lidke, Diane S., Ameer-Beg, Simon M., Martin-Fernandez, Marisa L., Ng, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Cell Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375452/
https://ncbi.nlm.nih.gov/pubmed/25762314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.01.005
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