Exploring the Enantioselective Mechanism of Halohydrin Dehalogenase from Agrobacterium radiobacter AD1 by Iterative Saturation Mutagenesis

Halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) shows great potential in producing valuable chiral epoxides and β-substituted alcohols. The wild-type (WT) enzyme displays a high R-enantiopreference toward most aromatic substrates, whereas no S-selective HheC has been reported to da...

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Vydáno v:Appl Environ Microbiol
Hlavní autoři: Guo, Chao, Chen, Yanpu, Zheng, Yu, Zhang, Wei, Tao, Yunwen, Feng, Juan, Tang, Lixia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Enzymology and Protein Engineering
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375331/
https://ncbi.nlm.nih.gov/pubmed/25681194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.04153-14
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