Key Residues for Controlling Enantioselectivity of Halohydrin Dehalogenase from Arthrobacter sp. Strain AD2, Revealed by Structure-Guided Directed Evolution

Halohydrin dehalogenase from Agrobacterium radiobacter AD1 (HheC) is a valuable tool in the preparation of R enantiomers of epoxides and β-substituted alcohols. In contrast, the halohydrin dehalogenase from Arthrobacter sp. AD2 (HheA) shows a low S enantioselectivity toward most aromatic substrates....

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Main Authors: Tang, Lixia, Zhu, Xuechen, Zheng, Huayu, Jiang, Rongxiang, Majerić Elenkov, Maja
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Enzymology and Protein Engineering
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318787/
https://ncbi.nlm.nih.gov/pubmed/22327597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.06586-11
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