Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice

Stimulation of endogenous β-cell expansion could facilitate regeneration in patients with diabetes. In mice, connective tissue growth factor (CTGF) is expressed in embryonic β-cells and in adult β-cells during periods of expansion. We discovered that in embryos CTGF is necessary for β-cell prolifera...

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Detalles Bibliográficos
Publicado en:Diabetes
Main Authors: Riley, Kimberly G., Pasek, Raymond C., Maulis, Matthew F., Peek, Jennifer, Thorel, Fabrizio, Brigstock, David R., Herrera, Pedro L., Gannon, Maureen
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2015
Assuntos:
Islet Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375083/
https://ncbi.nlm.nih.gov/pubmed/25392241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1195
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