Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

OBJECTIVE: Promotion of endogenous β-cell mass expansion could facilitate regeneration in patients with diabetes. We discovered that the secreted protein CTGF (aka CCN2) promotes adult β-cell replication and mass regeneration after injury via increasing β-cell immaturity and shortening the replicati...

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Bibliographic Details
Published in:Mol Metab
Main Authors: Riley, Kimberly G., Pasek, Raymond C., Maulis, Matthew F., Dunn, Jennifer C., Bolus, W. Reid, Kendall, Peggy L., Hasty, Alyssa H., Gannon, Maureen
Format: Artigo
Language:Inglês
Published: Elsevier 2015
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529497/
https://ncbi.nlm.nih.gov/pubmed/26266091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.05.002
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