Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk

Genome-wide association studies (GWAS) have uncovered >65 common variants associated with type 2 diabetes (T2D); however, their relevance for drug development is not yet clear. Of note, the first two T2D-associated loci (PPARG and KCNJ11/ABCC8) encode known targets of antidiabetes medications. We...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Segrè, Ayellet V., Wei, Nancy, Altshuler, David, Florez, Jose C.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2015
Fag:
Genetics/Genomes/Proteomics/Metabolomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375079/
https://ncbi.nlm.nih.gov/pubmed/25368101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0703
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