Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits

Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can cause a rare form of diabetes. However, it is unclear whether mitochondrial dysfunction is a primary cause of the common...

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Main Authors: Segrè, Ayellet V., Groop, Leif, Mootha, Vamsi K., Daly, Mark J., Altshuler, David
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920848/
https://ncbi.nlm.nih.gov/pubmed/20714348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001058
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