Combining Paclitaxel with ABT-263 Has a Synergistic Effect on Paclitaxel Resistant Prostate Cancer Cells

We assessed the capability of paclitaxel, one of the taxanes, to induce death in two prostate cancer lines, LNCaP and PC3. Paclitaxel drove an apoptotic pathway in LNCaP, but not in PC3 cells, in response to G2/M arrest. An examination of the levels of anti-apoptotic proteins revealed that Bcl-xl wa...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Wang, Chihuei, Huang, Shih-Bo, Yang, Min-Chi, Lin, Yi-Tsen, Chu, I-Hung, Shen, Ya-Ni, Chiu, Yueh-Ho, Hung, Shao-Hung, Kang, Lin, Hong, Yi-Ren, Chen, Chung-Hwan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374961/
https://ncbi.nlm.nih.gov/pubmed/25811469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120913
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