A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis

Autophagy helps deliver sequestered intracellular cargo to lysosomes for proteolytic degradation and thereby maintains cellular homeostasis by preventing accumulation of toxic substances in cells. In a forward mosaic screen in Drosophila designed to identify genes required for neuronal function and...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Tian, Xuejun, Gala, Upasana, Zhang, Yongping, Shang, Weina, Nagarkar Jaiswal, Sonal, di Ronza, Alberto, Jaiswal, Manish, Yamamoto, Shinya, Sandoval, Hector, Duraine, Lita, Sardiello, Marco, Sillitoe, Roy V., Venkatachalam, Kartik, Fan, Hengyu, Bellen, Hugo J., Tong, Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374850/
https://ncbi.nlm.nih.gov/pubmed/25811491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002103
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