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Angiotensin II-Induced Arterial Thickening, Fibrosis and Stiffening Involves Elevated Arginase Function

BACKGROUND: Arterial stiffness (AS) is an independent risk factor for cardiovascular morbidity/mortality. Smooth muscle cell (SMC) proliferation and increased collagen synthesis are key features in development of AS. Arginase (ARG), an enzyme implicated in many cardiovascular diseases, can compete w...

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Vydáno v:PLoS One
Hlavní autoři: Bhatta, Anil, Yao, Lin, Toque, Haroldo A., Shatanawi, Alia, Xu, Zhimin, Caldwell, Ruth B., Caldwell, R. William
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373900/
https://ncbi.nlm.nih.gov/pubmed/25807386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121727
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