Angiotensin II-Induced Arterial Thickening, Fibrosis and Stiffening Involves Elevated Arginase Function

BACKGROUND: Arterial stiffness (AS) is an independent risk factor for cardiovascular morbidity/mortality. Smooth muscle cell (SMC) proliferation and increased collagen synthesis are key features in development of AS. Arginase (ARG), an enzyme implicated in many cardiovascular diseases, can compete w...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bhatta, Anil, Yao, Lin, Toque, Haroldo A., Shatanawi, Alia, Xu, Zhimin, Caldwell, Ruth B., Caldwell, R. William
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373900/
https://ncbi.nlm.nih.gov/pubmed/25807386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121727
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