Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

AIMS: Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L-arginine depletion. Excessive arginase activity also can drive L-arginine metabolism towards the production of ornit...

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Vydáno v:Cardiovasc Res
Hlavní autoři: Bhatta, Anil, Yao, Lin, Xu, Zhimin, Toque, Haroldo A., Chen, Jijun, Atawia, Reem T., Fouda, Abdelrahman Y., Bagi, Zsolt, Lucas, Rudolf, Caldwell, Ruth B., Caldwell, Robert W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410953/
https://ncbi.nlm.nih.gov/pubmed/29048462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx164
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