Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

OBJECTIVE: We propose that metastatic epithelial ovarian cancer (EOC) is a potential therapeutic target for the oncolytic agent, Myxoma virus (MYXV). METHODS: Primary EOC cells were isolated from patient ascites and cultured as adherent cells or in suspension using Ultra Low-Attachment dishes. MYXV...

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Publicado no:Gynecol Oncol
Main Authors: Correa, Rohann J.M., Komar, Monica, Tong, Jessica G.K., Sivapragasam, Milani, Rahman, Masmudur M., McFadden, Grant, DiMattia, Gabriel E., Shepherd, Trevor G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373451/
https://ncbi.nlm.nih.gov/pubmed/22306204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2012.01.048
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