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MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4

Recent findings unexpectedly revealed that human TLR4 can be directly activated by nickel ions. This activation is due to the coordination of nickel by a cluster of histidine residues on the ectodomain of human TLR4, which is absent in most other species. We aimed to elucidate the role of MD-2 in th...

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Pubblicato in:PLoS One
Autori principali: Oblak, Alja, Pohar, Jelka, Jerala, Roman
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372398/
https://ncbi.nlm.nih.gov/pubmed/25803856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120583
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