Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

Development of contact allergy requires cooperation of adaptive and innate immunity. Ni(2+) stimulates innate immunity via TLR4/MD2, the bacterial LPS receptor. This likely involves receptor dimerization, but direct proof is pending and it is unclear if related haptens share this mechanism. We revea...

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Autors principals: Raghavan, Badrinarayanan, Martin, Stefan F, Esser, Philipp R, Goebeler, Matthias, Schmidt, Marc
Format: Artigo
Idioma:Inglês
Publicat: European Molecular Biology Organization 2012
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512400/
https://ncbi.nlm.nih.gov/pubmed/23059983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.155
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