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DNA demethylation by 5-aza-2′-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences
BACKGROUND: DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents that reverse this dysregulation is therefore an attractive possibility. To test h...
Gespeichert in:
| Veröffentlicht in: | Epigenetics Chromatin |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372267/ https://ncbi.nlm.nih.gov/pubmed/25806086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0004-x |
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