DNA demethylation by 5-aza-2′-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences

BACKGROUND: DNA methylation can be abnormally regulated in human disease and associated with effects on gene transcription that appear to be causally related to pathogenesis. The potential to use pharmacological agents that reverse this dysregulation is therefore an attractive possibility. To test h...

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Udgivet i:Epigenetics Chromatin
Main Authors: Ramos, María-Paz, Wijetunga, Neil Ari, McLellan, Andrew S, Suzuki, Masako, Greally, John M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372267/
https://ncbi.nlm.nih.gov/pubmed/25806086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0004-x
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