p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling

The predominant p63 isoform, ΔNp63, is a master regulator of normal epithelial stem cell (SC) maintenance. However, in vivo evidence of the regulation of cancer stem cell (CSC) properties by p63 is still limited. Here, we exploit the transgenic MMTV-ErbB2 (v-erb-b2 avian erythroblastic leukemia vira...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Memmi, Elisa Maria, Sanarico, Anna Giulia, Giacobbe, Arianna, Peschiaroli, Angelo, Frezza, Valentina, Cicalese, Angelo, Pisati, Federica, Tosoni, Daniela, Zhou, Huiqing, Tonon, Giovanni, Antonov, Alexey, Melino, Gerry, Pelicci, Pier Giuseppe, Bernassola, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372004/
https://ncbi.nlm.nih.gov/pubmed/25739959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500762112
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