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BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1
The DNA damage response (DDR) is crucial for genomic integrity. BRIT1 (breast cancer susceptibility gene C terminus-repeat inhibitor of human telomerase repeat transcriptase expression), a tumor suppressor and early DDR factor, is recruited to DNA double-strand breaks (DSBs) by phosphorylated H2A hi...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371995/ https://ncbi.nlm.nih.gov/pubmed/25733871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418335112 |
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