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Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO mice) exhibit brain mitochondrial dysfunction with reduced mitoc...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371978/ https://ncbi.nlm.nih.gov/pubmed/25733901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500877112 |
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