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Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO mice) exhibit brain mitochondrial dysfunction with reduced mitoc...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371978/ https://ncbi.nlm.nih.gov/pubmed/25733901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500877112 |
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