Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

Diabetes and insulin resistance are associated with altered brain imaging, depression, and increased rates of age-related cognitive impairment. Here we demonstrate that mice with a brain-specific knockout of the insulin receptor (NIRKO mice) exhibit brain mitochondrial dysfunction with reduced mitoc...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kleinridders, Andre, Cai, Weikang, Cappellucci, Laura, Ghazarian, Armen, Collins, William R., Vienberg, Sara G., Pothos, Emmanuel N., Kahn, C. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371978/
https://ncbi.nlm.nih.gov/pubmed/25733901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500877112
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