Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression

Akt is a robust oncogene that plays key roles in the development and progression of many cancers, including glioma. We evaluated the differential propensities of the Akt isoforms toward progression in the well-characterized RCAS/Ntv-a mouse model of PDGFB-driven low grade glioma. A constitutively ac...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Turner, Kristen M., Sun, Youting, Ji, Ping, Granberg, Kirsi J., Bernard, Brady, Hu, Limei, Cogdell, David E., Zhou, Xinhui, Yli-Harja, Olli, Nykter, Matti, Shmulevich, Ilya, Yung, W. K. Alfred, Fuller, Gregory N., Zhang, Wei
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371922/
https://ncbi.nlm.nih.gov/pubmed/25737557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414573112
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