Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation

Retroviruses cause immunodeficiency and cancer but also are used as vectors for the expression of heterologous genes. Nevertheless, optimal translation of introduced genes often is not achieved. Here we show that transfection into mammalian cells of lentiviral or gammaretroviral vectors, including t...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Gou, Yongqiang, Byun, Hyewon, Zook, Adam E., B. Singh, Gurvani, Nash, Andrea K., Lozano, Mary M., Dudley, Jaquelin P.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371913/
https://ncbi.nlm.nih.gov/pubmed/25737543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420477112
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items