Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation

Retroviruses cause immunodeficiency and cancer but also are used as vectors for the expression of heterologous genes. Nevertheless, optimal translation of introduced genes often is not achieved. Here we show that transfection into mammalian cells of lentiviral or gammaretroviral vectors, including t...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Gou, Yongqiang, Byun, Hyewon, Zook, Adam E., B. Singh, Gurvani, Nash, Andrea K., Lozano, Mary M., Dudley, Jaquelin P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371913/
https://ncbi.nlm.nih.gov/pubmed/25737543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420477112
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