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Retroviral vectors elevate coexpressed protein levels in trans through cap-dependent translation

Retroviruses cause immunodeficiency and cancer but also are used as vectors for the expression of heterologous genes. Nevertheless, optimal translation of introduced genes often is not achieved. Here we show that transfection into mammalian cells of lentiviral or gammaretroviral vectors, including t...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Gou, Yongqiang, Byun, Hyewon, Zook, Adam E., B. Singh, Gurvani, Nash, Andrea K., Lozano, Mary M., Dudley, Jaquelin P.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371913/
https://ncbi.nlm.nih.gov/pubmed/25737543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420477112
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