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Myosin VI deafness mutation prevents the initiation of processive runs on actin

Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (P(i)), from dependency on actin binding and...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Pylypenko, Olena, Song, Lin, Shima, Ai, Yang, Zhaohui, Houdusse, Anne M., Sweeney, H. Lee
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371908/
https://ncbi.nlm.nih.gov/pubmed/25751888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420989112
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