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Myosin VI deafness mutation prevents the initiation of processive runs on actin

Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (P(i)), from dependency on actin binding and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pylypenko, Olena, Song, Lin, Shima, Ai, Yang, Zhaohui, Houdusse, Anne M., Sweeney, H. Lee
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371908/
https://ncbi.nlm.nih.gov/pubmed/25751888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420989112
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