Genetic Association of CD247 (CD3ζ) with SLE in a Large-Scale Multiethnic Study

A classic T-cell phenotype in Systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters TCR signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohort...

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Detalhes bibliográficos
Publicado no:Genes Immun
Main Authors: Martins, Madalena, Williams, Adrienne H., Comeau, Mary, Marion, Miranda, Ziegler, Julie T., Freedman, Barry I., Merrill, Joan T., Glenn, Stuart B., Kelly, Jennifer A., Sivils, Kathy M., James, Judith A., Guthridge, Joel M., Alarcón-Riquelme, Marta E., Bae, Sang-Cheol, Kim, Jae-Hoon, Kim, Dam, Anaya, Juan-Manuel, Boackle, Susan A., Criswell, Lindsey A., Kimberly, Robert P., Alarcón, Graciela S., Brown, Elizabeth E., Vilá, Luis M., Petri, Michelle A., Ramsey-Goldman, Rosalind, Niewold, Timothy B., Tsao, Betty P., Gilkeson, Gary S., Kamen, Diane L., Jacob, Chaim O., Stevens, Anne M., Gaffney, Patrick M., Harley, John B., Langefeld, Carl D., Fesel, Constantin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371129/
https://ncbi.nlm.nih.gov/pubmed/25569266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2014.73
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